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Your Position: Home > Serpin E2

Serpin E2

Brief Information

Name:Sodium channel protein type IX alpha subunit
Target Synonym:Voltage-Gated Sodium Channel Subunit Alpha Nav1.7,HNE-Na,PN1,Sodium Channel, Voltage Gated, Type IX Alpha Subunit,Neuroendocrine sodium channel,Sodium channel protein type IX subunit alpha,Peripheral sodium channel 1,Sodium channel protein type 9 subunit alpha,GEFSP7,HSAN2D,Nav1.7,FEB3B,NE-NA,ETHA,SFNP,NAV1.7 Voltage-Gated Sodium Channel,NENA,SCN9A,Sodium Voltage-Gated Channel Alpha Subunit 9,Sodium Channel, Voltage-Gated, Type IX, Alpha Polypeptide,Sodium Channel, Voltage-Gated, Type IX, Alpha
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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Synonym Name

SERPINE2,Glia-derived nexin,GDN,Peptidase inhibitor 7,PI-7,Protease nexin 1,PN-1,Serpin E2,SerpinE2,PI7

Background

SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.

Clinical and Translational Updates

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